Analytical Study of Thrombocytopenia in Pregnant Women in Tishreen University Hospital (Causes, Complications, Management)

Alaa Marouf

doi:https://doi.org/10.14445/23939117/IJMS-V9I1P102

Research Article | Open Access

Volume 9 | Issue 1 | Year 2022 | Article Id. IJMS-V9I1P102 | DOI : https://doi.org/10.14445/23939117/IJMS-V9I1P102

Analytical Study of Thrombocytopenia in Pregnant Women in Tishreen University Hospital (Causes, Complications, Management)

Alaa Marouf, Firas Hussein, Louai Hasan

Citation :

Alaa Marouf, Firas Hussein, Louai Hasan, "Analytical Study of Thrombocytopenia in Pregnant Women in Tishreen University Hospital (Causes, Complications, Management)," International Journal of Medical Science, vol. 9, no. 1, pp. 9-13, 2022. Crossref, https://doi.org/10.14445/23939117/IJMS-V9I1P102

Abstract

The aims of this study are to determine the prevalence of thrombocytopenia during pregnancy, in addition to evaluating the etiologies and the outcomes of thrombocytopenia.
A prospective cohort study was conducted on 894 pregnant women. They are selected from the Department of Obstetrics and Gynecology, Tishreen University Hospital in Lattakia-Syria, between November 2020 and November 2021. Blood samples were taken, and a complete blood count CBC was performed to detect the presence of thrombocytopenia.
Results of the 894 women enrolled in the study, 75(8.4%) had thrombocytopenia. Benign gestational thrombocytopenia represented the most frequent cause of thrombocytopenia (80%), followed by immune thrombocytopenia (10.7%) and pre-eclampsia (4%). Other causes were rare, which consisted of disseminated intravascular coagulation (2.7%), Antiphospholipid syndrome (1.3%), and multiple myeloma (1.3%). The most frequent complications of thrombocytopenia were antepartum hemorrhage (8%), premature delivery (8%), and the rate of complications was the least in women with benign gestational thrombocytopenia than other etiologies. A cut of 80.000 of platelets yielded a sensitivity of 90% and specificity of 87.3% in predicting the final outcome, in which the rate of complications was higher in women with platelet count <80.000.

Keywords

Thrombocytopenia, Pregnancy, Prevalence, Complications.

References

[1] Reese,J;Peck,J;Deschamps,D., Platelet Counts During Pregnancy. N Engl J Med, 379(32) (2018).
[2] Kadir, R; Mclintock, C.,Thrombocytopenia and Disorders of Platelet Function in Pregnancy. Semin Thromb Hemost, 37 (2011) 640-52.
[3] Cines, D; Levine, L., Thrombocytopenia in Pregnancy, (2017). Blood.130:2271-2277.
[4] Fogerty, A (2018). Thrombocytopenia in Pregnancy: Mechanisms and Management. Transfusion Medicine Reviews,32 (2018) 225-229.
[5] Ciobanu,A;Colibaba,S;Peltecu,G., Thrombocytopenia in Pregnancy.Maedica.11 (2016) 55-60.
[6] Bockenstedt, P., Thrombocytopenia in Pregnancy. Hematol Oncol Clin North Am, 25 (2011) 293-310.
[7] Wang, X; Xu, Y; Luo, W., Thrombocytopenia in Pregnancy with Different Diagnoses: Differential Clinical Features, Treatments, and Outcomes.Med, 96 (2017) 7561.
[8] Myers, B(2012). Diagnosis and Management of Maternal Thrombocytopenia in Pregnancy. Br J Haematol, 158 (2012) 3.
[9] Myers, B., Review Thrombocytopenia In Pregnancy.Obstet Gynaecol, 11 (2009) 177-183.
[10] Gernsheimer,T;James,A;Stasi,R., How I Treat Thrombocytopenia In Pregnancy. Blood, 121 (2013) 38-47.
[11] Boehlen,R;Hohlfeld,P;Thomas,V., Platelet Count at Term Pregnancy: A Reappraisal of The Threshold. Obstetrics&Gynecology, 95 (2000) 29-33.
[12] Wang,X;Xu,Y;Feng,H.,Thrombocytopenia in Pregnancy with a Different Diagnosis.Medicine, (2017) 96:29(E7561).
[13] Khadra, M; Al-Husban, N; Fram, K., Thrombocytopenia in Pregnancy; Prevalence, Causes and Fetomaternal Outcome, 1(21) (2020)
[14] Gerbasi FR, Bottoms S, Farag A, Mammen E. Increased Intravascular Coagulation Associated with Pregnancy. Obstet Gynecol 75 (1990) 385–9.
[15] Verdy E., Bessous V., Dreyfus M., Kaplan C., Tchernia G., Uzan S.: Longitudinal Analysis of Platelet Count and Volume in Normal Pregnancy,Thromb. Haemost., 77 (1997) 806.
[16] Parnas M., Sheiner E., Shoham-Vardi I., Burstein E., Yermiahu T., Levi I., Et Al., Moderate to Severe Thrombocytopeniai Pregnancy, Eur. J. Obstet. Gynecol.Reprod. Biol., 128(163) (2006) .
[17] Tygart SG, Mcroyan DK, Spinnato JA, Mcroyan CJ, Kitay DZ. A Longitudinal Study of Platelets Indices During Normal Pregnancy. Am J Obstet Gynecol , 154 (1986) 883–7.
[18] Ahmed Y, Van Iddeking B, Paul C, Sullivan MHF, Elder MG. Retrospective Analysis of Platelet Number and Volumes in Normal Pregnancy And In Pre-Eclampsia. Br J Obstet Gynaecol, 100 (1993) 216–20.
[19] Giles C. The Platelet Counts And Means Platelet Volume. Br J Haematol, 48 (1981) 31–7.
[20] Burrows RF, Kelton JG. Incidentally Detected Thrombocytopenia In Healthy Mothers And Their Infants. N Engl J Med, 319 (1988) 142–5.
[21] Sill PR, Lind T, Walker W. Platelet Values During Normal Pregnancy. Br J Obstet Gynaecol , 92 (1985) 480-3.
[22] Rinder HM, Bonan JL, Anandan S, Rinder CS, Rodrigues PA, Smith BR. Noninvasive Measurement of Platelet Kinetics in Normal And Hypertensive Pregnancies. Am J Obstet Gynecol, 170 (1994) 117–22.
[23] Lurie S. Changes In Platelet Volume and Count During Pregnancy: A Longitudinal Study. Gynecol Obstet Invest, 40 (1995) 71–2.
[24] Burrows RF, Kelton JG. Fetal Thrombocytopenia and its Relation to Maternal Thrombocytopenia. N Engl J Med , 329 (1993) 1463– 6.
[25] Boehlen F, Hohlfeld P, Extermann P, De Moerloose P. Maternal Antiplatelet Antibodies in Predicting the Risk of Neonatal Thrombocytopenia.Obstet Gynecol, 93 (1999) 169–73.